Target profile

Last updated 4 months ago

When searching for a target, in addition to the list of diseases associated with it, you will also see at the top of the page the ‘View TARGET profile’ link e.g. 'View BRAF profile'. Click on the link to get information on your target of interest, outside the context of associated diseases.

In the target profile page, you will see the target official symbol, its description and synonyms, the latter two provided by UniProt. Scroll down to see detailed information on the target (e.g. Drugs, Protein interactions) and the original resource of the data (e.g. ChEMBL, OmniPath DB):

We also include links to the Structural Genomics Consortium when a Target Enabling Package (or TEP) is available, such as for the CDK12 drug target; and details of 182 unique high-quality chemical probes for 187 different targets from the Structural Genomics Consortium (SGC), the Chemical Probes Portal and Open Science Probes, in addition to links to Probe Miner if potential chemical probes are available for a given target.

Check the target profile page for BRPF1 to find both curated, high-quality probes, and potential probes developed for this target, from Chemical Probes Portal and Probe Miner, respectively.

Top tip

Explore our target profile pages with annotations to enable target prioritisation. Check BRAF for an example.

Check our Everything you wanted to know about a drug target series of quick tutorials on our YouTube channel to learn how to explore the target profile page.