When you search for a target, you will get an overview of all diseases associated with it. You can filter the results of associations by Data types (e.g. Genetic associations, Somatic mutations) and Therapeutic area (e.g. Genetic disorder, Skin disease).
The associations are provided in three different views as summarised below.
In this view, we list all diseases associated with target, ordered by the association score, which is colour coded. The darker the blue, the stronger the association. When there is no evidence to support the association, the cells in this table are coloured in white. Evidence from highly specific terms (child terms) of the disease ontology is aggregated to broader, parent terms. If you search for BRAF, you will see evidence for associations with both broader disease terms, such as neoplasm, as well as more specific child terms such as ovarian teratoma.
You can sort the associations by the scores for individual data types (e.g. Genetic associations, Somatic mutations). Use the search box to restrict the diseases displayed in the Table view. In our BRAF example above, if you type "lung", you will restrict the table to show diseases with the word 'lung' in their names only.
In this view, we group diseases into 'bubbles' based on the disease ontology. Large bubbles correspond to a therapeutic area and consist of smaller bubbles representing diseases within this area. A disease can belong to several therapeutic areas and therefore can appear within more than one large bubble.
The strength of the association between the target and a disease is represented by the size of the bubble and the shade of its blue colour; the larger the bubble and the darker the blue, the stronger the association.
In the Tree view, you can visualise the evidence across the therapeutic areas in a tree that represents the relationships of diseases. Therapeutic areas have a square symbol (e.g. Genetic disorders), while the diseases (e.g. ovarian carcinoma) are represented as circles. The squares and circles are colour coded in blue, and the darker the blue, the stronger the association.
Head to the Open Targets Platform to see all targets associated with SETDB1 and find out which view is more useful to you.